Binding site-based classification of coronaviral papain-like proteases
نویسندگان
چکیده
منابع مشابه
Interaction of papain-like cysteine proteases with dipeptide-derived nitriles.
A series of 44 dipeptide nitriles with various amino acids at the P2 position and glycine nitrile at position P1 were prepared and evaluated as inhibitors of cysteine proteinases. With respect to the important contribution of the P2-S2 interaction to the formation of enzyme-inhibitor complexes, it was focused to introduce structural diversity into the P2 side chain. Nonproteinogenic amino acids...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2005
ISSN: 0887-3585
DOI: 10.1002/prot.20802